1. Practicing temporary eating resulted in slight weight loss in obese adults after 12 weeks.
Evidence rating level: 2 (good)
Resistant hypertension, which remains uncontrolled despite maximum medical therapy, affects up to 10% of patients diagnosed with hypertension. A number of smaller, non-randomized and / or non-blind studies have shown that denervation of the renal arteries significantly lowers blood pressure in patients with resistant hypertension. About 10% of morbidity and mortality in the UK result from obesity disease. Intermittent fasting has shown promising results in weight loss in both animals and humans, as well as improvements in glucose metabolism and lipid profiles in humans. However, this approach, which alternates total or partial energy restriction with unrestricted energy, is restrictive and demanding and is therefore not used in clinical practice. Time-Restricted Eating (TRE), or the 16: 8 diet, is a less strict format that restricts diets from consuming only within an 8-hour window each day. Small samples and different results and experimental protocols in previous studies provide little information about the true effects of TRE on weight and lipid profile. In this pilot cohort study, 50 participants with obesity (mean age 50 years, mean BMI = 35, 74% female) were asked to eat only during an 8-hour window every day while water, diet drinks or coffee or tea were without sugar or milk allowed for the remaining 16 hours. Participants completed questionnaires and had their weight measured at the start of the study, 6 weeks and 12 weeks in addition to their blood pressure and lipid profile measured at the start and end of the study. Weekly phone calls monitored their compliance from weeks 2 to 5. With the primary result as adherence, 80% and 78% provided data after 6 and 12 weeks, with 58% of participants continuing to adhere to TRE for at least 5 days / week through week 12. Those who provided follow-up data and adhered to the TRE intervention for at least 5 days / week saw greater weight loss after 6 and 12 weeks, with 2.5+ 1.7 kg versus 1.0 + 1.3 kg (p = 0.003) after 6 weeks and 3.5+ 2.7 kg versus 1.3+ 2.0 kg. p = 0.001 after 123 weeks. Overall, 26% of the participants lost at least 5% of their body weight within 12 weeks. No effect on blood pressure or lipid profile was observed. The most common barriers to compliance involved social activities such as eating out, having visitors, and having a drink after work, while participants said planning ahead, using distraction, and / or drinking water or black coffee to cope with hunger To finish. While the extent of weight loss from TRE intervention was modest, previous studies with more complex regimens produced similar results. Overall, these results are encouraging and conducting a randomized controlled trial using a similar TRE protocol with a longer follow-up period could provide further support for these results.
Click here to read the study in PLOSONE
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